We are interested in cell-to-cell communication. At present, our efforts are focused on signaling that depends on the heterotrimeric G protein complex. Much of our work is devoted to understanding novel mechanisms for activating this pathway therefore we are looking at organisms quite divergent to animal cells where much is already understood about G protein signaling. Using the diversity of life to discover the diversity of cell signaling is a powerful approach.
The JonesLab showed that most eukaryotic cells outside of the animal group have a very different mechanism for activation mechanism. Whereas, the rate-limiting step for G protein activation is nucleotide exchange on the Galpha subunit of the complex, in plant cells and protists, this step is spontaneous. Therefore, the need for a G protein coupled receptor to catalyze this GTP for GDP nucleotide exchange is not needed in plant cells and protists. We showed that the reaction that returns G protein activation (GTP-bound) to the inactive state is the rate-limiting step and is mediated by a receptor like protein that accelerates this “off” reaction. However, this is not the only mechanism to control the pool size of the activated G protein. The JonesLab takes a wide variety of experimental and theoretical approaches to solve central basic problems in cell biology with the intent that our work will translate into improved quality of life, create sustainable agriculture, and make us better stewards of the Earth. Mathematical modelers, biochemists, microscopists, physiologists, geneticists are welcomed to join the JonesLab team. Please see the available positions by clicking the link above.