Assistant Professor, Biochemistry and Biophysics Department, Biology Department
Affiliations: Department of Biochemistry and Biophysics; Integrative Program for Biological and Genome Sciences (iBGS); Lineberger Comprehensive Cancer Center (LCCC)
3360 Genome Sciences Building
(919) 962-8132 (office)
The lab studies how genes function within the three-dimensional context of the nucleus to control development and prevent disease. We combine genomic approaches (ChIP-Seq, ChIA-PET) and genome editing tools (CRISPR) to study the epigenetic mechanisms by which transcriptional regulatory elements control gene expression in embryonic stem cells. Our current research efforts are divided into 3 areas: 1) Mapping the folding pattern of the genome 2) Dynamics of three-dimensional genome organization as cells differentiate and 3) Functional analysis of altered chromosome structure in cancer and other diseases.