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Congratulations to Chanin Tolson and Lela Lackey (Alain Laederach’s lab) whose paper was recently published in the Biophysical Journal. Their paper, titled “Comparative Visualization of the RNA Suboptimal Conformational Ensemble In Vivo,” describes a novel approach for visualization of RNA structure using multi-dimensional scaling techniques to better normalize the Boltzmann suboptimal ensemble of RNA structures. In practice this approach is far more robust and allows accurate interpretation of the structural consequences of the cellular environment on RNA folding.

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