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Congratuations to Xuejie Chen, a postdoc in Darrel Stafford’s Lab who recently published a paper in Blood titled “A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle.” In this study, the authors adapted a cell-based screening approach to identify several drugs from the NIH Clinical Collection drug library that caused bleeding disorders by impacting the biosynthesis of active coagulation factors. The paper also explored the mechanisms of action and prevention of drug induced bleeding disorders.

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