Darrel Stafford’s Lab publishes in “Bioorganic & Medicinal Chemistry Letters”

Da-Yun Jin (right) and Xuejie Chen (left), members of Dr. Darrel Stafford’s Lab, have published a paper in Bioorganic & Medical Chemistry Letters in collaboration with Dr. Craig Williams at the University of Queensland, Australia. The article was titled “Determining the necessity of phenyl ring π-character in warfarin”. The authors systematically substituted the phenyl ring of warfarin, and evaluated its effect on the inhibition potency of the target enzyme, vitamin K epoxide reductase. Their results demonstrated the importance of both the annulene conferred π-interactions and ring size in warfarin’s activity. Read more >>