The opportunity and excitement provided by research in the biomedical sciences has never been greater. With the sequence of the human genome and that of nearly every model organism in hand, the scientific community is poised to make great strides in our understanding of basic biological processes, and their relationship to disease. As a graduate student in Molecular, Cell and Developmental Biology (MCDB) at Carolina you can be part of the cutting-edge research that makes this such an exhilarating time.

Our faculty and students use a wide variety of modern approaches, including genomics, molecular genetics, cell biology, and biochemistry, to study basic biological processes. We excel in using model organisms, including single-celled organisms such as E. coli and S. cerevisiae, the plant Arabidopsis, and animals like C. elegans, Drosophila, Xenopus, and mouse. Learn more about our research and the program by following the links below.

To learn more about this discipline, see below:


Research Environment

A DIVERSE AND COLLABORATIVE DEPARTMENT

The Department of Biology is composed of over 50 faculty actively engaged in research that spans the entire scope of modern biology, from the disciplines of cell, molecular, and developmental biology through the areas of ecology, physiology and behavior. The department as a whole forms a very interactive group, which fosters an environment emphasizing collaboration and resource sharing.

There are many formal and informal research ties among the diverse groups within the Department. A few examples within MCDB provide a glimpse of the range of relationships. The Bloom and Salmon labs share the sixth floor of Fordham Hall, and share an interest in mitosis and the mechanisms of chromosome segregation. They approach this problem from different directions, with the Bloom lab using the power of yeast genetics and the Salmon lab using innovative microscopy techniques to study vertebrate cells. This has lead to a very fruitful collaboration that has resulted in numerous publications, and has led to a situation where open doors join the two labs into a single unit. The Goldstein and Peifer labs share an interest in cell polarity, though they focus on different organisms and focused on different molecules. The Dangl and A. Jones labs share an interest in signal transduction events that underlie different aspects of plant physiology. Their different areas of expertise led to a collaboration to identify the molecule which induces an important event during bacterial pathogenesis. The Copenhaver, C. Jones, and Sekelsky labs are interested in meiotic gene conversion, and have a collaborative grant to study this process in Arabidopsis and Drosophila, through laboratory experiments and population genetic analyses. Many more informal ties also join different labs, including joint Drosophila meetings between the Duronio, C. Jones, Searles, Crews, Peifer, and Sekelsky groups, and joint C. elegans meetings between members of the Goldstein, Ahmed, and Lieb labs.

A CLOSE-KNIT UNIVERSITY COMMUNITY

The cells shown in the figure are of two types: one are mesophyll cells containing chloroplasts that fluoresce red under IV light and the other are specialized vascular cells that have cell walls that fluoresce yellow under UV light. After hormone induction, the mesophyll cells will transdifferentiate synchronously into the vascular cells (from Groover and Jones, 1999).

The Department of Biology is embedded in a very strong university-wide research community. Our Department provides a bridge connecting the biological research conducted in basic science departments such as chemistry, physics, and computer science to the biomedical research community in the School of Medicine. There are numerous departments in the Medical school staffed by research scientists interested in the full array of scientific disciplines from biochemistry to cell biology to physiology. Because the medical school and the undergraduate campuses are directly adjacent, all of these scientists are located within a short walk of one another and of the biology department.

Formal ties between Biology and the School of Medicine include joint participation into three interdepartmental graduate training programs (the Curriculum in Genetics and Molecular Biology, the IBMS Program, and the Curriculum in Neurobiology) and in the joint post-doctoral training program of the Lineberger Cancer Center. These bring scientists from different departments together at scientific retreats and on student’s thesis committees. There are also numerous links based on scientific interests. These have led to collaborative efforts such as those between the Salmon lab and Keith Burridge in Cell and Developmental Biology, Bob Duronio and Yue Xiong in Biochemistry, and joint lab meetings between the Lieb Lab and Brian Strahl in Biochemistry. They also have resulted in the formation of local interest groups with participants in both Biology and in other Departments, such as those in cancer genetics, the cytoskeleton, Drosophila molecular genetics, yeast chromatin, and cardiovascular biology–these groups meet on a regular basis to discuss their research. Furthermore, the Department of Biology is part of a campus-wide Program in Molecular Biology and Biotechnology and the Carolina Center for Genome Sciences.

AN UNEQUALED SCIENTIFIC COMMUNITY IN THE TRIANGLE

Our geographical location near the Research Triangle Park in North Carolina places us in one of the countries leading areas for cutting-edge research in biotechnology. Three major research Universities anchor the three points of the triangle: UNC-CH in Chapel Hill, Duke University in Durham and North Carolina State University in Raleigh. All are within an easy drive or bus ride, with Duke 12 miles and N.C. State 30 miles away. Thus UNC and Duke are no more distant than the medical school and main campus often are at other universities. The result is extensive interchange between the two campuses for seminars and joint lab meetings between groups sharing similar interests. The academic scientists are joined by a large number of corporate and government scientists in the more than 150 companies in Research Triangle Park (RTP), which is situated between the three campuses. RTP includes large pharmaceutical and biotechnology companies including the U.S. headquarters of GlaxoSmithKline, Bayer Health Care’s Biological Products Division, and Syngenta. The RTP also houses the National Institute of Environmental Health Sciences (one of the NIH institutes), as well as one of the main scientific units of the Environmental Protection Agency. In addition, numerous start-up biotechnology companies like Paradigm Genetics and Trimeris add to the scientific community.

The academic, corporate and government scientists are active participants in many local interest groups, including the Triangle Arabidopsis Group, the “Triangle Smaller Eukaryotes (i.e. yeast) Meeting”, both of which meet at the centrally located North Carolina Biotechnology Center, and a monthly C. elegans supergroup meeting here at UNC. Together, these resources make the Triangle an outstanding place to be a scientist.

Training Philosophy

Regardless of whether your future leads you into academia, industry, or some other career option, as a graduate student you have two tasks: 1) to learn how to be a scientist, and 2) to obtain a broad training in many different areas of science. The Department of Biology at UNC provides a superb environment to carry out both of these tasks. The road to becoming a scientist involves learning to plan, carry out and interpret experiments. One of the best ways to obtain this sort of training is in work on a model biological system such as those studied in our department. The strengths of these model systems are the many tools available to attack a problem, allowing students to work at the cutting edge of biology. The boundaries formerly separated different disciplines have disappeared; one can no longer be simply a geneticist or just a cell biologist. Rather, one must attack a problem with all of the tools at hand. A student who carries out thesis work studying a fundamental biological problem in one of our labs will be exposed to a wide array of technological approaches.

All of our labs offer the opportunity to use genetics as one approach– genetics allows the researcher to ask the organism what molecules are important for a given biological process, without built-in biases on the part of the investigator. Our labs also offer the opportunity to attack problems with the tools of modern cell biology, using cutting-edge imaging equipment alongside colleagues who are pushing the limits in these areas. They also offer the opportunity to get your feet wet in biochemistry, asking about the function of and the interactions between molecules required for the process you are studying. Many of our laboratories have begun using the most recent genomics approaches also. Our students have an opportunity to carry out experiments in each of these areas, achieving the broad training they need to become independent scientists. This broad training is illustrated by the publication records of our recent students and the postdoctoral opportunities of which they have been able to take advantage.

In addition to lab work, our Department offers a number of other training opportunities. Students in our Department will spend the first year taking a set of courses tailored to their own interests and needs. They attend our weekly Department seminars, and also have an opportunity to attend the seminars in other Departments, Curricula, and programs on our campus and in the broader Research Triangle area. Our students are trained to present their work in yearly seminars for their fellow graduate students, and in yearly meetings with their thesis advisory committees. They also have the opportunity to present their work at National and International scientific meetings in their area of study.

Degree Requirements

4 courses during the first 2 years

  • 2 must be 3-hour (minimum) graduate-level lecture courses
  • 1 must be a seminar/journal club course
  • the 4th can be either a lecture or seminar/journal club course
  • Specific courses are NOT mandated.

Lecture courses should include two of the following major topic areas:

  • Molecular Biology (e.g. BIOL 632)
  • Genetics (e.g. GNET 621)
  • Cell/Developmental Biology (e.g. BIOL 649, BIOC 643, PHCO 740-742, PHCO 744, CBPH 850 & 851)
  • Biochemistry/Biophysics (e.g. BIOC 601)
  • Microbiology/Immunology (e.g. MCRO 614, MCRO 630, MCRO 635)
  • Other appropriate courses (Bioinformatics for example) can be selected in consultation with an advisor.

Attend weekly departmental seminar series

Dissertation Research:

Each semester that you are engaged in dissertation research you will enroll in a 900-level course (exact numbers change depending on your advisor). At the end of the semester you will need to complete a brief report of your research progress, have it signed by your advisor and submit it to the Graduate Student Service Manager. Click here for the report form.

Written Exam:

The written exam is taken by the student at the beginning of the fall semester of his or her second year. Students choose 3 areas (of 4 offered) for concentration. They are given a group of up to 10 papers for each area approximately one month before the exam. They receive questions and answer them at 5 hrs/area over several days at the end of the month, in a written format. The exams are then graded by the Biology MCDB Written Exam Committee. Students who do not pass may be asked to retake all or part of the exam the following year. Click here for a more detailed description of the written exam process.

Feasibility Exam:

The feasibility exam is a comprehensive oral examination that is accompanied by a written research proposal. This examination must be held before the end of the spring semester of the third year. This translates into approximately 2 years after the written exam. For the feasibility and oral exam, students write a feasibility proposal on their thesis topic in the NIH NRSA style. The proposal should have preliminary data that has been generated; however, the report should be primarily focused on the logic and feasibility of the project. A member of the thesis committee who is not the mentor will chair this examination. All members of the student’s doctoral committee will examine the student. Grading will be pass or fail. A pass requires the approval of no less than 2/3 (in most instances 4 out of 5) of the committee. Click here for a more detailed description of the feasibility examAfter completion of the Feasibility Exam, students continue to have yearly committee meetings.

Students are required to have a first-author (or co-first author) research paper (not a review) accepted in a peer-reviewed journal for graduation. Exemptions to this requirement are expected to be extremely rare and will be reviewed on a case-by-case basis by the Graduate Studies Committee and in consultation with the student’s advisor and thesis committee.

Graduate student thesis committees will be chaired by a committee member who is a regular member of the Biology department and who is NOT the student’s primary thesis advisor (or co-advisor). Selection of the chair shall be a collaborative choice between the student and the committee. A majority of the committee must be regular members of the UNC Biology graduate faculty (i.e. Professors, Associate Professors, and Assistant Professors of Biology, as well as a few additional UNC faculty who have been specially appointed by the Department; if you are unsure of the status of a prospective committee member, then please consult the Graduate Student Services Manager). After satisfying this majority requirement, additional committee members can include anyone is qualified to conduct the doctoral examinations and advise the student on their dissertation research. People who are active UNC faculty require no special approval. People who are NOT active UNC faculty may serve as committee members, subject to approval first by the Director of Graduate Studies, then by the Dean of the Graduate School. To request approval, submit the proposed committee member’s curriculum vitae to the Graduate Student Services Manager.

Thesis committee meetings shall begin by the graduate student being asked to step out of the room to allow committee members to discuss the student’s progress among themselves. Upon being invited back into the room, the student’s primary thesis advisor (or co-advisors) will be asked to step out to allow the student to discuss their progress with the committee. The advisor (or co-advisors) will be invited back in and the full meeting will commence. At the conclusion of the meeting the committee may (but is not required to) ask the student to step out of the room again so that they can reach consensus.

After completion of the Feasibility Exam, students continue to have yearly committee meetings. Students must schedule a pre-thesis defense meeting at least 2 months prior to their anticipated thesis defense date, and prior to setting the date.  The committee must give the student permission to defend. Once this date is set, please inform the Graduate Student Services Manager. The defense consists of a written thesis that has been read and approved by the committee, a public seminar describing the thesis work, and a private oral defense of the thesis work with the committee.

Students must be registered during the semesters in which exams are taken. Residence credit of four semesters is required for a Ph.D. degree. The degree time limit for Ph.D. students is 8 years from the date of registration.

The Department believes strongly in the value of teaching, and, therefore, requires each student to serve as a teaching assistant (TA) in a course in the Biology Department for at least on Fall or Spring semester.

In addition to coursework, attending seminars also greatly helps students gain exposure to broader research and new ways to ask and answer scientific questions. It is strongly recommended that students attend the lunch bunch seminars on Fridays and attend relevant Biology departmental seminars.

To maintain eligibility to continue in The Graduate School, a student must not receive a grade of F or F*, or receive a grade of L in nine or more credit hours.

Refer to the Graduate School Handbook for additional information regarding required registration, doctoral degree requirements, and other relevant information.

Please inform the Graduate Student Services Manager when any of the above exams and meetings are to take place as forms may need to be prepared.

Financial Support

As a student in the Molecular, Cell, and Developmental Biology program at UNC, you will be financially supported by your PIs grants to provide a competitive stipend, cover your tuition, fees, and health insurance or by a TAship. Typically these sources of support are provided throughout your graduate career as long as you remain in good academic standing, though the finances of individual labs may vary. The Graduate Funding Information Center (https://gradfunding.web.unc.edu) is a great resource that can assist current and prospective graduate students find appropriate funding opportunities. Through some of the funding databases, you can set up alerts to notify you when new opportunities are available based on information you provide.

Former Students

COMING SOON!

How to Apply

For students interested in research in Molecular, Cell, and Developmental Biology our application, interview, and admission process is now handled through the Biological and Biomedical Sciences Program. Note that students interested in Evolution, Ecology, and Organismal Biology (EEOB) must apply through a different mechanism (refer to the EEOB application page for information).  Students interested in the interface of MCDB and EEOB should contact one or more prospective faculty advisers for guidance on how to apply.

Click here to begin the Biological and Biomedical Sciences Program application process.

The Biological and Biomedical Sciences Program (BBSP) is unified way for prospective students interested in the Department of Biology or any of the other 12 participating graduate programs in the biological and biomedical sciences at the University of North Carolina at Chapel Hill to apply for graduate study. BBSP acts as a common portal through which students begin their graduate studies at UNC-CH. Students admitted to UNC-CH through BBSP initially have no commitment to any specific Ph.D. program. At the end of the first year students select a thesis research lab and join a PhD program or department (usually one of the programs in which your faculty preceptor is a member). We are excited about the flexibility this program offers to our students during their first year. For a more complete description of the application process visit the BBSP Apply page.

While BBSP students have the freedom to choose coursework and rotations from any of the participating programs, including the Department of Biology, if you are interested only in research in Molecular, Cell and Developmental Biology in the Department of Biology PhD program you should still apply through BBSP. You will then begin fulfilling the Department’s degree requirements (e.g. taking the appropriate courses) in your first year, and will rotate with faculty in the Department of Biology.

 

Find faculty doing research in: