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Jill Dowen

Assistant Professor, Biochemistry and Biophysics Department, Biology Department

Contact Information

Office: 3360 Genome Sciences Building
Email: jilldowen[at]
Office Phone: (919) 962-8132

Dowen Lab Website


Department of Biochemistry and Biophysics

The lab studies how genes function within the three-dimensional context of the nucleus to control development and prevent disease. We combine genomic approaches (ChIP-Seq, ChIA-PET) and genome editing tools (CRISPR) to study the epigenetic mechanisms by which transcriptional regulatory elements control gene expression in embryonic stem cells.  Our current research efforts are divided into 3 areas: 1) Mapping the folding pattern of the genome 2) Dynamics of three-dimensional genome organization as cells differentiate and 3) Functional analysis of altered chromosome structure in cancer and other diseases.